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Inflammation
Inflammation is protective in the short term and corrosive when it lingers. Learn the levers that shift the balance.
Showing all 32 articles
Inflammation is protective in the short term and corrosive when it lingers. Learn the levers that shift the balance.
Showing all 32 articles
Boswellia is the gum resin of the frankincense tree, standardized for a family of compounds called boswellic acids. It is among the most studied botanicals for its role in a balanced inflammatory response and everyday joint comfort.
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C-reactive protein is a protein the liver releases into the bloodstream in response to inflammatory signals. Measured with a simple blood draw, it is one of the most widely studied markers clinicians use to gauge the overall level of systemic inflammation in the body.
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Chronic stress keeps the body's stress-response system switched on, altering the daily rhythm of the hormone cortisol. Over time this shift is studied for its association with a less balanced immune and inflammatory response, making stress one of the most modifiable lifestyle levers in a longevity plan.
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The cyclooxygenase (COX) and lipoxygenase (LOX) pathways are two enzyme routes that convert the fatty acid arachidonic acid into potent signaling molecules. Together they generate the prostaglandins, thromboxanes, and leukotrienes that help orchestrate the body's inflammatory, pain, and immune responses.
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Curcumin is the principal bioactive polyphenol in the turmeric root, giving the spice its golden-orange color. It is one of the most extensively studied plant compounds for its interactions with NF-kB and other pathways that help regulate the body's inflammatory response.
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Dietary polyphenols are a large family of plant compounds, concentrated in colorful fruits, vegetables, tea, coffee, and cocoa, that are studied for their antioxidant and immune-modulating activity. Much of the research explores how they interact with the gut, cellular signaling, and the body's inflammatory pathways.
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The erythrocyte sedimentation rate, or ESR, measures how quickly red blood cells settle in a tube of blood over one hour. Because inflammation-related proteins make cells clump and fall faster, ESR is a long-used, indirect marker studied to reflect systemic inflammatory activity.
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Fermentable dietary fibers are the plant carbohydrates your own enzymes cannot break down, so gut bacteria ferment them into short-chain fatty acids like butyrate, acetate, and propionate. These metabolites are widely studied for their role in nourishing the gut lining and shaping a balanced immune and inflammatory tone.
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Ginger is the rhizome of Zingiber officinale, prized in kitchens and traditional medicine and rich in pungent compounds called gingerols and shogaols. It is among the most studied botanicals for how those compounds may influence the enzymes and signaling that shape the body's inflammatory tone.
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Glutathione is a naturally occurring tripeptide antioxidant that helps neutralize free radicals and support cellular detoxification. It is studied for its central role in maintaining redox balance and protecting tissues from oxidative stress.
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Green tea is a minimally oxidized tea leaf rich in polyphenol catechins, most notably epigallocatechin-3-gallate (EGCG). These compounds are among the most studied plant antioxidants for their role in redox balance and the modulation of inflammatory signaling pathways.
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The gut microbiome is the vast community of bacteria and other microbes living in your intestines, in constant dialogue with the immune system. Its composition and metabolic output are widely studied for their role in shaping the gut barrier, immune education, and systemic inflammatory tone.
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Homocysteine is a sulfur-containing amino acid produced when the body processes methionine from dietary protein. Its level in blood is widely studied as a marker associated with vascular inflammation, cardiovascular risk, and the status of B-vitamin-dependent metabolic pathways.
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Interleukin-6 is a versatile cytokine that cells release to coordinate the body's response to injury, infection, and stress. As a measurable blood marker, it offers a window into inflammatory signaling that research links to metabolic, cardiovascular, and immune health.
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Lipid peroxidation is the chain-reaction oxidation of the fatty molecules that build cell membranes and lipoproteins. Its by-products are widely studied in blood and urine as markers that help gauge the body's overall burden of oxidative stress.
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Magnesium is an essential dietary mineral that acts as a cofactor for hundreds of enzymatic reactions across the body. Population and clinical research explores associations between magnesium adequacy and lower levels of common inflammatory markers such as C-reactive protein.
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Mitochondrial oxidative stress describes the imbalance that arises when the reactive oxygen byproducts of cellular energy production outpace the antioxidant systems meant to neutralize them. Research associates this state with cellular aging, low-grade inflammation, and metabolic health.
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NF-kB is a family of transcription factors that act as a central control switch for the inflammatory and immune response. When activated, it moves into the cell nucleus and turns on the genes for many cytokines, enzymes, and defense proteins the body uses to respond to threats.
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The NLRP3 inflammasome is a multi-protein sensor inside immune cells that detects a wide range of danger and stress signals. When triggered, it assembles to activate the potent inflammatory messenger IL-1beta, making it a central hub research connects to both protective immunity and chronic, low-grade inflammation.
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The Nrf2 pathway is a signaling system that senses oxidative and inflammatory stress and, in response, activates hundreds of protective genes. It is one of the most widely studied coordinators of the cell's antioxidant and detoxification defenses.
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EPA and DHA are long-chain marine omega-3 fatty acids the body builds into cell membranes and converts into specialized signaling molecules. They are among the most studied nutrients for their role in a balanced inflammatory response and the active resolution of inflammation.
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Physical activity is any bodily movement that raises energy expenditure above rest, from structured exercise to daily motion. Research consistently associates regular movement with a lower resting inflammatory tone and a more balanced, responsive immune system over time.
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Quercetin is a widely distributed plant flavonoid found in foods like onions, apples, and capers. It is among the most studied dietary flavonoids for its potential to stabilize mast cells, quench free radicals, and modulate inflammatory signaling.
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Reactive oxygen species are highly reactive oxygen-containing molecules that cells produce as a normal byproduct of energy metabolism and immune defense. At balanced levels they act as signals, but in excess they are associated with oxidative stress that can damage cells and fuel chronic inflammation.
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Resveratrol is a plant polyphenol found in grape skins, red wine, and berries that plants produce as a defense compound. It is among the most studied natural molecules for its association with sirtuin signaling, cellular stress responses, and a balanced inflammatory tone.
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Sleep quality describes how deep, continuous, and well-timed your nightly rest is, not just how many hours you log. Restorative sleep is among the most studied lifestyle levers for a balanced inflammatory tone, healthy immune signaling, and daytime resilience.
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Specialized pro-resolving mediators are signaling molecules the body makes from omega-3 and omega-6 fatty acids to actively switch off inflammation once it has done its job. Research characterizes them not as blockers of inflammation but as the natural on-signal for its resolution.
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Superoxide dismutase is a family of metal-containing enzymes that form the body's first line of defense against superoxide, a reactive byproduct of normal metabolism. It is widely studied for its role in converting this free radical into less harmful molecules and keeping cellular oxidative stress in check.
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TNF-alpha is a signaling protein, or cytokine, that immune cells release to switch on and amplify inflammation. It is one of the most studied markers of immune activation and is closely associated with chronic, low-grade inflammatory states.
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Visceral adiposity is the fat stored deep in the abdomen around organs like the liver and intestines, rather than just under the skin. This depot is highly metabolically active and, when it expands, is associated with the kind of chronic, low-grade inflammation that research links to metabolic and cardiovascular health.
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Vitamin D is a fat-soluble nutrient that the body converts into a hormone acting through receptors found across immune tissue. Its status, measured in blood, is widely studied for its association with immune regulation, inflammatory tone, bone health, and overall resilience.
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Zinc is an essential trace mineral required by hundreds of enzymes and by the immune cells that shape the body's inflammatory response. Research explores how adequate zinc status is associated with more measured, well-regulated immune signaling.
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